The 31-year-old will miss the trip to Old Trafford after suffering a thigh injury in Saturday's win over Bordeaux
Paris Saint-Germain have been dealt a further blow ahead of their Champions League last-16 clash against Manchester United with the news that Edinson Cavani and Thomas Meunier will miss the game.
The Uruguayan striker limped off of PSG's 1-0 win over Bordeaux with a thigh problem after scoring the Ligue 1 encounter's only goal of the game.
Coach Thomas Tuchel admitted on Sunday that it would be "very difficult" for Cavani to be fit for Tuesday's first leg at Old Trafford.
The French champions have since assessed the 31-year-old and ruled that he will not be fit to make the trip to Manchester.
"The examinations carried out revealed a lesion of a tendon on the right hip," a statement from the club read. "The treatment and the duration of unavailability will depend on the recovery in the coming days."
The absence of Cavani, who has 21 goals from 25 games in all competitions this season, comes as a big blow for the runaway Ligue 1 leaders. Tuchel's team are already without Brazilian attacker Neymar, who has been out since January with a broken metatarsal, while Marco Verratti is also a doubt.
Cavani was replaced by Kylian Mbappe in the Bordeaux match and will return to his place in the starting XI in the Champions League.
With two members of their star trio missing, Tuchel is worried they must change their strategy for the meeting with Ole Gunnar Solskjaer's team.
"Without [Neymar], maybe without Marco, maybe without [Cavani], now we need a plan D," he told reporters .